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Creatine is a key player in heart contraction and energy metabolism. In heart failure, creatine and phosphocreatine decrease because of decreased expression of the creatine transporter, and because phosphocreatine degrades to prevent adenosine triphosphate (ATP) exhaustion. This causes decreased contractility reserve of the myocardium and correlates with left ventricular ejection fraction, and it is a predictor of mortality. Creatine effectiveness in this case may be because anthracyclines reduce expression of the creatine transporter, and because of the pleiotropic antioxidant properties of creatine. Moreover, creatine may also reduce concomitant muscle damage by anthracyclines

In this talk, Prof. Maurizio Balestrino PhD (University of Genova, Italy) presents about the ""Role of Creatine in the Heart: Health and Disease"".

Access the full article for free ⬇️⬇️
Balestrino, M. Role of Creatine in the Heart: Health and Disease. Nutrients 2021, 13, 1215. https://doi.org/10.3390/nu13041215


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