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Related episodes:

The R-Files episode 1:    • An introduction to the study of RAPAM...  
The R-Files episode 2:    • Off-Label Rapamycin Experiences & Dos...  
The R-Files episode 3:    • Rapamycin's possible SIDE EFFECTS & B...  
The R-Files episode 4:    • Rapamycin's SURPRISING Effects on Age...  
The R-Files episode 5:    • Comparing Bryan Johnson's RAPAMYCIN D...  

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The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered attention for its potential anti-aging properties and has attracted research interest for its ability to extend lifespan and delay age-related diseases in various model organisms, including yeast and mice.

As we've mentioned before, we read every comment on our social media and Youtube channels and often learn a lot from your questions and feedback. For this episode, we collected comments you left containing questions about rapamycin. Many of the questions focus on rapamycin dosing, diet and exercise changes while taking rapamycin, and potential side effects. We also appreciated your curiosity about the state of rapamycin research, evidence for benefit in different model organisms, and the nuances of experimental conditions in rapamycin studies. Keep the questions coming!

0:00 Introduction
0:46 What diseases, if any, have clearly been shown to improve on rapamycin?
7:25 Is there evidence for rapamycin benefits in monkeys?
8:44 Should we change our diets in any way on days we take rapamycin?
11:30 Questions around protein intake on rapamycin days
17:22 Can I exercise a few hours before taking rapamycin?
18:16 Thoughts on the rebound/overshooting of mTOR after rapamycin?
20:41 Is it better to dose rapamycin every two weeks or every week?
25:02 Can people develop resistance to rapamycin over time? If so, would varying the dosage and/or dosing frequency mitigate this from occurring?
26:34 How low is "low" blood sirolimus levels before the next dose of weekly rapamycin? What should we target for the trough levels of blood sirolimus testing?
27:52 Is there evidence that rapamycin affects bone loss in any way?
30:16 How can we compare the evidence for SGLT2 inhibitors with that for mTOR inhibitors? Which makes the stronger case for use in humans?
35:49 What is unique about TriviumVet's rapamycin formulation? Is it being sold yet?
37:00 Laboratory mice are kept in very sterile conditions. Could rapamycin be making their immune systems less active, and could the longevity of these mice be caused by the lower collateral damage that occurs in the body as a result of this turned-down immune system?
38:44 Has the Dog Aging Project rapamycin study produced any lifespan data?
40:19 Wrapping up

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

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