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Related episodes:

The R-Files episode 1:    • An introduction to the study of RAPAM...  
The R-Files episode 2:    • Off-Label Rapamycin Experiences & Dos...  
The R-Files episode 3:    • Rapamycin's possible SIDE EFFECTS & B...  
The R-Files episode 4:    • Rapamycin's SURPRISING Effects on Age...  
Matt Kaeberlein's ALLERGIC REACTION to Medication While on Rapamycin:    • Matt Kaeberlein's ALLERGIC REACTION t...  
Are DEXA scans ACCURATE? What YOU NEED to KNOW:    • Are DEXA scans ACCURATE? What YOU NEE...  
The Importance of Body Composition & Ways YOU can measure it:    • The Importance of Body Composition & ...  

The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered attention for its potential anti-aging properties and has attracted research interest for its ability to extend lifespan and delay age-related diseases in various model organisms, including yeast and mice.

In our fifth episode of the R-Files, Matt shares insights from his recent course of off-label rapamycin use, which he started in January 2024 and plans to continue for at least the next month or two. He describes improvements in joint pain and body fat loss as well as an unexpected bacterial infection, and speculates about whether rapamycin may have contributed to any of these effects. He also discusses rapamycin's half-life in his blood, which is significantly lower than that reported in the published literature.

0:00 Trailer
0:44 Introduction
3:47 Aches and pains
4:29 Effects on weight and body fat loss
9:24 Matt's rapamycin half-life
14:19 Bryan Johnson's rapamycin half-life
17:06 Matt's bacterial infection
21:57 Wrapping up

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!