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Our recent episode on the Interventions Testing Program's recent tests on various longevity interventions sparked some interesting debate on X. City of Hope National Medical Center's Alfred E. Mann Family Foundation Chair in Diabetes and Cancer Metabolism Charles Brenner made a remark about the potential negative effects of rapamycin on humans, while Ponce De Leon Health Chief Operating Officer Mike Muldoon plugged the calcium alpha-ketoglutarate supplement Rejuvant (the ITP tests reported no lifespan extension of alpha-ketoglutarate on mice). Matt responded to these comments on X and some interesting back and forth with Charles and Mike ensued.

In this episode, Matt and Nick take a magnifying glass to Charles' and Mike's feedback and examine the published data—and some unpublished data—to consider and respond to their claims. They also discuss the allure of phrases such as "scientifically proven" and "clinically proven" in marketing, and the importance of approaching such phrases with a critical mindset and an eye towards study robustness and methodology as well as the researchers' impartiality.

0:00 Trailer
1:06 Introduction
3:09 Charles Brenner's take on how rapamycin will affect humans
6:05 Matt's response to Charles' take
14:59 Mike Muldoon's take on Rejuvant, a calcium alpha-ketoglutarate supplement
15:30 Matt's response to Mike's take
20:48 A follow-up post from Mike
21:04 Matt's response to Mike's post
39:14 Wrapping up

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

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https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!