The Riverside Expressway section of I-64 connects the Sherman Minton Bridge and Louisville's West End with the Downtown area and the Kennedy Interchange.

Highlights: Sherman Minton Bridge (IN/KY State Line), JCT I-264, McAlpine Locks & Dam, Louisville & Portland Canal, (Downtown Louisville), Ohio Riverfront, KFC Yum! Center, George Rogers Clark Bridge flyover, Louisville Slugger Field, Kennedy Interchange: JCT I-65; JCT I-71