The Riverside Expressway section of I-64 connects the Sherman Minton Bridge and Louisville's West End with the Downtown area and the Kennedy Interchange.

Highlights: (Downtown Louisville), Kennedy Interchange: JCT I-65; JCT I-71, Ohio Riverfront, Louisville Slugger Field, George Rogers Clark Bridge flyover, KFC Yum! Center, McAlpine Locks & Dam, Louisville & Portland Canal, JCT I-264, Sherman Minton Bridge (IN/KY State Line)