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In this episode, we discuss three findings that have made the rounds in the geroscience and healthspan spaces in recent months. They relate to three universally-relevant topics: pregnancy, exercise, and diet.

The first study suggested that women who have been pregnant at least once age faster than women who had never been pregnant, controlling for social, environmental, and genetic variation and measuring aging rate via six epigenetic clocks.

The second study found a connection between workout timing and cardiovascular disease, microvascular disease, and all-cause mortality risk in adults with obesity. Evening workouts appeared to lead to the greatest morbidity and mortality benefits.

The third study, which researchers presented at a recent American Heart Association meeting, demonstrated a positive relationship between time-restricted eating—that is, eating all daily meals in a short time window rather than throughout the day—and risk of dying from heart disease.

It's been an interesting time for geroscience-related findings. Matt and Nick chat about the three studies, discussing their potential limitations, possible mechanisms underlying the observed longevity effects, and further work that would provide greater depth to our understanding of healthspan and longevity.

0:00 Trailer
0:48 Introduction
1:28 The Washington Post article: How pregnancy may speed in the aging process
3:13 What the study did
6:55 Potential confounders in the study
7:41 Does pregnancy accelerate biological aging?
11:59 Theories about the tradeoff between reproduction and longevity
14:25 Mechanisms that might be involved in a relationship between reproduction and longevity
15:32 Differences in results between epigenetic clocks
19:33 What Matt would want to see in studies examining reproduction and longevity
20:33 The New York Times article: When Is the Best Time to Work Out?
22:01 What the study did
27:35 Mechanisms that might be involved in a relationship between workout time and longevity
30:30 What Matt would want to see in studies examining workout time and longevity
32:25 Factors to consider in choosing a workout time
33:03 The Washington Post article: The intermittent fasting trend may pose risks to your heart
34:46 What the study did
38:55 Limitations of the study
47:23 Advice for people doing intermittent fasting
49:51 Dietary recall surveys
50:43 Matt's thoughts on media headlines describing the three studies
53:40 Summing up

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!