Examining the Top 15 emptiest parts of the U.S. I look at the parts of the country that have the fewest number of people over a large area. These are places with little to no development, few if any roads, and few if any farms and ranches- just true wilderness. If you're a city slicker or suburbanite, you may be surprised at just how much of the U.S. is empty and remote. This is true middle of nowhere.