Learning points:
The distribution of metastases is determined by the locations of stem-cell niches and BM stromal cells including regulated fat cells
The balance between osteoblastic and osteolytic mechanisms determines the nature of the metastases observed on x-ray methods
Combining appearances on MRI with CT enables an expanded classification of bone metastases according to their underlying cellularity & matrix appearance
The BM cell signalling status of bone metastases can be inferred from MRI/CT/bone scan appearances