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For years AM Instruments validation team has been offering a smoke test service. Our expertise, together with the experience, generated an operating mode that can be summarized in a fundamental concept: as AM Instruments Validation Manager Roberto Stroppa says: ”Smoke tests cannot and must not be a simple airflow control, but a careful analysis of all elements that contribute to the contamination control. It is no coincidence that in the last years inspection agencies have used smoke tests as verification test that considers both airflows, but also, and especially, operative dynamics”. This way the “in operation” state becomes prevalent in comparison to the one “at rest”.