Aka a run without a "broken" character.
PoDD's lunatic is often seen as the hardest in the series to 1cc... with a high-tier character.
So you can imagine how it's like without a high-tier character.
The real threat in this game are the bosses. Cancelling them out with a level 4 spell is a must strategy.

Yumemi is a beast. Whether she gets hit or not is entirely up to her, as she can dodge pretty much everything.