This week’s episode is a collaborative conversation between Dr. Paul and Dr. Mohammad Alo, board-certified cardiologist and Personal Trainer. They both offer their differing perspectives about lipids, LDL, cardiovascular disease, and seed oils.

00:00:00 Podcast begins
00:03:08 Dr. Alo’s thoughts on cardiovascular risk
00:10:18 Dr. Paul’s thoughts on cardiovascular risk & insulin resistance
00:26:38 Metabolic health of Americans
00:32:53 LDL, APOEB & atherosclerosis
00:38:53 How fasting insulin & insulin resistance relate to atherosclerosis
00:47:48 Arteries vs. veins & atherosclerosis
01:06:38 Genes vs. lifestyles & insulin resistance
01:14:23 Seed oils vs. saturated fat
01:36:38 The problems with “totality of evidence”
01:47:38 Concluding statements

References:
Connect with Dr. Alo: https://www.dralo.net/links

A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans
An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality
Can linoleic acid contribute to coronary artery disease?s
Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease
Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment
Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a)
Diet and serum sex hormones in healthy men
Dietary Fatty Acids and the 10-Year Incidence of Age-Related Macular Degeneration
Dietary intakes of polyunsaturated fatty acids and indices of oxidative stress in human volunteers
Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins--the Jerusalem Nutrition Study: high MUFAs vs high PUFAs
Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects
High cholesterol may protect against infections and atherosclerosis
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Hyperlipidaemia does not impair vascular endothelial function in glycogen storage disease type 1a
Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults
Is Butter Back? A Systematic Review and Meta-Analysis of Butter Consumption and Risk of Cardiovascular Disease, Diabetes, and Total Mortality
Is glycogen storage disease 1a associated with atherosclerosis?
LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature
Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies
Low-Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events
Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease
Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans
Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation
Plasma lipoprotein (a) levels in men and women consuming diets enriched in saturated, cis-, or trans-monounsaturated fatty acids
Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population
Premature atherosclerosis associated with monogenic insulin resistance
Prevalence of Optimal Metabolic Health in American Adults
Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology
Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients
The association between linoleic acid levels in colostrum and child cognition at 2 and 3 y in the EDEN cohort
Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018
Quantification of apo[a] and apoB in human atherosclerotic lesions
4-hydroxynonenal causes impairment of human subcutaneous adipogenesis and induction of adipocyte insulin resistance


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