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Heart disease is still the number one killer in the world, yet most people don’t actually understand what markers put them most at risk.

The general consensus is there are two types of cholesterol—the good and the bad—the good is thought to be high-density lipoproteins or HDL, and the bad is low-density lipoproteins or LDL. But we now know from research that it's much more complicated than that—there are actually various sizes and densities of these lipoproteins.

Today on The Doctor’s Farmacy, I’m excited to talk to one of the leading lipidologists, Dr. Ronald Krauss, all about lipoproteins, what they do in the body, what they mean for heart disease risk, and why a typical lipid panel alone is insufficient.

Dr. Krauss is a Senior Scientist at Children’s Hospital Oakland Research Institute, a Professor of Medicine at UCSF, and an Adjunct Professor of Nutritional Sciences at UC Berkeley. Dr. Krauss’s research aims to understand how to best prevent cardiovascular disease through early detection and management of its major risk factors: most notably, elevated levels of blood cholesterol and lipoproteins. He has published over 450 research articles and reviews on metabolic, genetic, dietary, and drug effects on plasma lipoproteins and the risk of coronary artery disease, with over 100,000 citations of this work.

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Research mentioned in this episode: https://pubmed.ncbi.nlm.nih.gov/37425...

00:00 Intro
01:17 The History of Heart Disease
03:39 Cholesterol vs Lipoproteins
08:15 Normal Cholesterol Levels
12:53 LDL Particles
15:00 Saturated Fat
19:43 Meats
20:43 Is Meat a Concern
22:08 Observational Studies
30:00 ApoB Test
33:30 Statistics
37:15 LDL
46:15 Lean Mass Hyperresponsive vs Poor Metabolic Health
51:35 Lipid Testing
54:35 Low Carb Diet