When people exercise as part of a treatment for alcohol abuse disorder it reduces their volume of alcohol consumption. But why? One reason may be FGF21. FGF21 – a hormone produced during vigorous exercise – prevents cravings for alcohol and animal studies suggest it may even be used as a drug to treat excessive alcohol use.

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CHAPTERS
00:00:00 - Introduction
00:00:24 - Why vigorous exercise matters
00:00:54 - Altering brain reward
00:01:25 - Factors that raise FGF21
00:01:52 - Does exercise type matter?
00:02:49 - Evidence from animals – reducing consumption 50 percent
00:04:15 - An FGF21 feedback loop may protect the liver
00:04:43 - Exercise may help treat alcohol use disorder (human evidence)
00:05:37 - Concluding thoughts

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REFERENCES:
Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit
Exercise as a Useful Intervention to Reduce Alcohol Consumption and Improve Physical Fitness in Individuals With Alcohol Use Disorder: A Systematic Review and Meta-Analysis

#Exercise #Alcohol #FGF21