By the time we are ready to settle even the nearest other planetary systems, we will have changed. The simple passage of so many generations will have changed us. Necessity will have changed us. We’re an adaptable species.

It will not be we who reach Alpha Centauri and the other nearby stars, it will be a species very like us, but with more of our strengths and fewer of our weaknesses. More confident, far seeing, capable, and prudent.

For all our failings, despite our limitations and fallibilities, We Humans are Capable of Greatness.

- Carl Sagan

Sadly he didn't live long enough to see VR Chat Knuckles.