Episode 1 of the second season of Children's Med Dallas picks up where the first season concluded. Two-year-old Rylynn Riojas remains in desperate need of a heart at the beginning but her family soon learns that a donor heart for Rylynn has been found. Viewers are also introduced to Dr. Andrew Koh, director of the stem cell transplant program at Children's, and one of his patients, Sophia Tilley, a 14-year-old girl in need of a bone marrow transplant to battle her leukemia.