In this episode I explore the history and pathology of Parkinson's disease. I use anecdotes from fascinating patient anecdotes, such as that of cardiologist Thomas Graboys, to review the clinical manifestations of the disease. I discuss how Adolf Hitler's Parkinson's disease may have influenced the course of World War II, and I review the history of how the frozen addicts led to the development of the MPTP model of the disease. I also retell the development of the Contursi genetic model of Parkinson's disease. The podcast also discusses the risk factors, and the uncertainties that surround the cause of the disease.