How Psychedelics Work & Psilocybin vs. SSRIs w/ Dr. Robin Carhart-Harris
The Psychedelic Scientist The Psychedelic Scientist
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 Published On Apr 16, 2021

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I recently had the pleasure of interviewing, podcast-style, leading psychedelic researcher Dr. Robin Carhart-Harris!

We covered a lot of topics, spanning from his current thinking on how psychedelics work, to the recent clinical trial comparing psilocybin therapy to the SSRI antidepressant drug escitalopram.

Here are some timestamps to help you navigate:

Introduction 0:00

How do psychedelics work? 1:21
Hierarchical predictive processing 6:30
The Relaxed Beliefs Under pSychedelics (REBUS) model 7:30
Reflecting on the plausibility of endogenous psychedelics 8:48
The serotonin 2A system as a "change system" 10:45
Pivotal mental states, context dependency, and psychosis 12:42

When does the serotonin 2A receptor get naturally activated by serotonin? 17:00

Brain imaging research with psychedelics 24:41

Linking brain dynamics to the dynamics of the psychedelic experience; neurophenomenology 28:41

Psilocybin vs. escitalopram: study design 33:42

Psilocybin vs. escitalopram: results and reflections 38:52

Neuroscape psychedelics division at UCSF 51:38


The chat was recorded on April 8th, 2021.
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More info about me:

Manesh Girn is a Neuroscience PhD student at McGill University and has been lead or co-author on over a dozen scientific publications and book chapters on topics including psychedelics, meditation, daydreaming, and brain networks.

Manesh currently has ongoing collaborations with Robin Carhart-Harris and others at the Imperial College Center for Psychedelic Research and is investigating the brain changes underlying psilocybin, LSD, and DMT.

  / mgirnneuro  
https://www.researchgate.net/profile/...

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