Carlo Colosimo, MD, FEAN, Santa Maria University Hospital, Terni, Italy, talks about the challenges associated with the diagnosis and treatment of multiple system atrophy (MSA), an atypical parkinsonian syndrome. MSA can be relatively similar clinically to Parkinson's disease (PD), making the diagnosis challenging; however, because MSA tends to progress more rapidly than PD, an early and accurate diagnosis is essential to give patients the correct prognosis and counseling. An early MSA diagnosis is also important for including patients in clinical trials evaluating potential disease-modifying treatments. Recently, the Movement Disorders Society developed new criteria for the diagnosis of MSA with the aim of improving diagnostic accuracy, particularly in the early disease stages. This interview took place at the 2022 International Congress of Parkinson's Disease and Movement Disorders in Madrid, Spain.

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