OSU-CHS is home to the OSU College of Osteopathic Medicine, recognized by U.S. News & World Report in 2012 as America's Most Popular Medical School. Home to the Center for Rural Health and a national leader in TeleHealth, OSU-CHS works to further OSU's land grant mission by serving the underserved in Oklahoma.

OSU-CHS also houses the School of Biomedical Sciences, School of Forensic Sciences and School of Health Care Administration.