This video is about rate determining step in cholesterol synthesis. Cholesterol biosynthesis rate limiting step or cholesterol synthesis regulated step is catalyzed by an enzyme HMG CoA reductase. HMG COA reductase converts HMG COA to mevalonate by using NADPH. HMG COA reductase is regulated allosterically, covalent modification, regulated the gene level by SREBP and SCAP, and by insulin and glucagon.
In this video I have explained in detail how cholesterol synthesis or cholesterol biosynthesis is going on in the cytoplasm of our cells. Cholesterol is synthesized by the condensation of acetyl CoA molecules eventually forming 27 carbon cholesterol molecule. While explaining cholesterol synthesis I have also explained different uses of farnesylpyrophosphate into dolichol, ubiquinol (CoQ10), and prenylation process.

Video link for cholesterol biosynthesis
   • Cholesterol Biosynthesis  

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