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In this journal club episode of The Metabolic Link, we explore the "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain’s energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harry Campbell, proposes that mitochondrial dysfunction forces the brain into a hypermetabolic state, leading to manic episodes.

We discuss how this groundbreaking research links bipolar disorder to epilepsy and how therapeutic ketosis—through diet or supplementation—might restore energy balance, reduce manic episodes, and complement traditional medications.

With the potential to reshape psychiatric treatment, you won't want to miss this paper or journal club episode! Read the full paper here: https://www.nature.com/articles/s4138...

Special thanks to the sponsors of this episode:
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In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!