Our understanding of the microbiome’s intricate role in bodily functions is still in its infancy. However, we know it influences not only our health but also our longevity. Nobel Prize-winning biochemist Jennifer Doudna has recently ventured into microbiome research, aiming to genetically edit microbes within us to prevent and treat diseases like childhood asthma.

Doudna’s team has introduced a novel technique, DNA-editing All-in-one RNA-guided CRISPR Cas Transposase (DART). This method employs a CRISPR-Cas enzyme to target specific DNA sequences and insert a bar-coded transposon (chromosome segment that can undergo transposition). The team successfully edited individual E. coli strains within a microbial community, focusing on disease-associated genes.

Highlights:
​0:08 - Introduction to the microbiome and its impact on health and longevity
​0:39 - The crucial role of the microbiome in digestion and nutrient absorption
​0:56 - The influence of the microbiome on mood and mental health
​1:23 - Imbalance in the microbiome linked to various health issues
​1:53 - A diverse and balanced microbiome as a common trait among centenarians
​2:05 - The potential impact of the microbiome on mental well-being
​2:33 - Understanding the microbiome unlocks a new level of understanding our bodies
​2:55 - The key to a healthy long life lies in the microscopic world within us

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