Published On Nov 9, 2020
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#LyticCycleOfBacteriophage
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About this video-
The T4 virus initiates an Escherichia coli infectionby binding OmpC porin proteins and lipopolysaccharide (LPS) on the surface of E. colicells with its long tail fibers (LTF).A recognition signal is sent through the LTFs to the baseplate. This unravels the short tail fibers (STF) that bind irreversibly to the E. coli cell surface. The baseplate changes conformation and the tail sheath contracts, causing GP5 at the end of the tail tube to puncture the outer membrane of the cell.
The lysozyme domain of GP5 is activated and degrades the periplasmic peptidoglycan layer. The remaining part of the membrane is degraded and then DNA from the head of the virus can travel through the tail tube and enter the E. coli cell.
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