Location: Highmark Stadium
Attendance: 70,542
Final score: Bills 34, Cardinals 28
Records: Bills (1-0), Cardinals (0-1)

Next opponent: Bills at Dolphins on Thursday, September 12 at 8:15 pm ET
Bills Mafia was welcomed back to Highmark Stadium as the Bills (1-0) defeated the Cardinals (0-1) 34-28 in their home opener.
Quarterback Josh Allen led the way, throwing for 232 yards and 2 touchdowns, adding 41 yards on the ground and two rushing touchdowns. RB James Cook added in yards 71 rushing and 32 yards receiving. LB Terrel Bernard led all defenders with 11 tackles and EDGE Greg Rousseau added in 3.0 sacks and a forced fumble.