🧠 In today’s video Dr. Dane Newville will discuss the mechanisms behind Sirolimus and its many benefits in reversing skin aging.

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The information presented in the following video are based upon the experience and training of the presenter and scientific information currently available. The suggestions in this presentation are not meant to be a substitute for medical evaluation and treatment. The presenter does not recommend changing or adding medications or supplements without consulting your personal physician. The presenter specifically disclaims any liability arising directly or indirectly from the use of this presentation.

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References:
1: Liao Z, Yeo HL, Wong SW, Zhao Y. Cellular Senescence: Mechanisms and Therapeutic Potential. Biomedicines. 2021;9(12):1769. doi:https://doi.org/10.3390/biomedicines9...
2: Chung CL, Lawrence I, Hoffman M, et al. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. GeroScience. 2019;41(6):861-869. doi:https://doi.org/10.1007/s11357-019-00...
3: Samanta D. Topical mTOR (mechanistic target of rapamycin) inhibitor therapy in facial angiofibroma. Indian Journal of Dermatology, Venereology, and Leprology. 2015;81(5):540. doi:https://doi.org/10.4103/0378-6323.163800
4: Deng Z, Chen M, Liu Y, et al. A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea. EMBO Molecular Medicine. Published online March 18, 2021. doi:https://doi.org/10.15252/emmm.202013560
5: Franco, A. C., Aveleira, C., & Cavadas, C. (2022). Skin senescence: mechanisms and impact on whole-body aging. Trends in Molecular Medicine, 28(2), 97–109. https://doi.org/10.1016/j.molmed.2021...