The Florida State Seminoles defeated the Duquesne Dukes, 47-7, to open the 2022 season. The Seminoles rolled on the ground with three running backs going for over 100 yards in the game, Treshaun Ward with 127 yards and 2 touchdowns, Trey Benson with 105 yards and a touchdown and Lawrance Toafili with 101 yards and a touchdown.