Will Ferrell and John C. Reilly – the legendary duo from Step Brothers and Talladega Nights – reunite in Holmes & Watson, a unique and comic take on the world’s greatest detective, Sherlock Holmes, and his faithful companion, Dr. John Watson. The game is afoot, or “a going,” as Holmes proclaims, when a dead body is discovered in Holmes’ birthday cake at Buckingham Palace. It seems the perpetrator is their longtime nemesis, criminal mastermind Professor James Moriarty (Ralph Fiennes), but the famed sleuth has doubts. As their investigation uncovers one twist after another, Holmes and Watson face the greatest threat of their partnership. The master sleuth and his dependable partner must remain united to find the killer, save the Queen, and restore the reputation of the world’s greatest crime-solving duo – if the case doesn’t tear them apart first.