In the 1970s, naive Gru auditions for a group of supervillains called the Vicious 6 after they abandon their leader, the legendary fighter Wild Knuckles. When the audition turns sour, Gru and his Minions go on the run with the Vicious 6 hot on their tails. Somehow, Gru manages to find a source for guidance -- Wild Knuckles himself -- and soon discovers that even bad guys need a little help from their friends.