In Dresden, Germany, a constellation of institutions, including the Max Planck Institute for the Physics of Complex Systems (MPIPKS) and the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), collaborate to blur the traditional boundaries between biology and physics. These multidisciplinary efforts drive groundbreaking discoveries. How did this innovative approach begin in Dresden? How does biology benefit from physics, and what new physics can emerge inspired by biological systems? Join us for a fascinating conversation with Prof. Anthony Hyman, director of the MPI-CBG; Prof. Frank Jülicher, director of the MPI-PKS; Prof. Kai Simons, director emeritus of the MPI-CBG; and prof. Jonathon Howard, former director of the MPI-CBG. This discussion takes you on a journey starting from the very foundation of MPI-CBG. They explore the importance of interdisciplinary science, the challenges of working in such an environment with diverse backgrounds, and how they found their unique path to scientific collaboration.