The success of your MALDI-TOF mass spectrometry analysis depends largely on how the sample is prepared. There are a number of choices to be made when preparing a MALDI-TOF sample, each of which has its own advantages and disadvantages.

Resources for MALDI-TOF sample preparation:

Sigma-Aldrich Analytix Guide to MALDI-Mass Spectrometry: http://www.niu.edu/analyticallab/_pdf...
Bruker Guide to MALDI Sample Preparation: https://www.bruker.com/fileadmin/user...
Sigma-Aldrich List of Matrix Substances for MALDI-MS: http://www.sigmaaldrich.com/analytica...
MALDI-TOF ChemWiki: http://chemwiki.ucdavis.edu/Core/Anal...
UC Irvine MALDI Sample Preparation Guide: http://www.chem.uci.edu/~jgreaves/mas...
WU St. Louis MALDI Sample Preparation General Recommendations: http://msr.dom.wustl.edu/maldi-sample...
MIT MALDI-TOF Sample Preparation Guide: http://web.mit.edu/speclab/www/PDF/DC...
SD State MALDI Sample Preparation Guide: https://www.sdstate.edu/chem/mass-spe...